Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis.
The recently discovered Nesfatin-1 plays a role in appetite regulation as a satiety factor through hypothalamic leptin-independent mechanisms.Nesfatin-1 is co-expressed with Melanin-Concentrating Hormone WEB DESIGN SCULPTING PASTE (MCH) in neurons from the tuberal hypothalamic area (THA) which are recruited during sleep states, especially paradoxic